PITTSBURGH -- Pirates second baseman Josh Harrison was removed from Wednesday's game vs. the Cubs in the third inning with discomfort in his left ankle.
Harrison turned the ankle in the first inning, when he was aboard via a walk and Gregory Polanco lined out to center. Thinking the ball had a chance to fall for a hit, Harrison was running aggressively toward second. When he braked to reverse his path, "I turned the ankle, pretty badly."
Harrison remained in the game, playing second, before suffering another episode to the ankle on a defensive play in the top of the second. He fielded Darwin Barney's grounder in the basepath, and tried to tag John Baker, who was running from first. As Baker spun away from him, Harrison again turned the ankle, although he did make a throw to first to retire the batter.
When Harrison's turn to bat came around again in the third, Clint Barmes hit for him, then stayed in the game to play second base.
"I'll come in [Thursday] to get some treatment, and we'll see how it feels," Harrison said. "At various times, we've all turned ankles. This one hurt pretty good."
Even if Harrison's absence is only temporary, having him forced out of the game came as another blow to a team that has lost three key players in the previous three days.
Starting pitchers Gerrit Cole (shoulder fatigue) and Francisco Liriano (strained left oblique) landed on the disabled list, as did regular second baseman Neil Walker, who underwent an emergency appendectomy Monday night.
Tom Singer is a reporter for MLB.com and writes an MLBlog Change for a Nickel. He can also be found on Twitter @Tom_Singer. Stephen Pianovich is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.