After his 55th pitch of the night, Liriano walked to the back of the mound, indicating something was wrong. A trainer took a look and talked with the lefty, who threw a few warmup pitches after the consult, but decided he could no longer pitch.
After the game, Hurdle gave a strong indication Liriano will miss at least his next start.
"I'm not a doctor. A left oblique strain, it might be a medical record if a guy can come back in four days and pitch," Hurdle said. "We have that on our side if we want to break a record. With what's going on, we'll make a better decision [Wednesday]."
Liriano had an MRI on Wednesday which confirmed the injury. Liriano noted he must have tweaked something just on one pitch and said he was still feeling some soreness when he spoke with reporters after the game, nearly three hours since he pitched. He added it's the first time he's had an ailment like this in his career and initially thought it was just a cramp.
A veteran lefty, Liriano is 1-6 with a 4.60 ERA in 14 starts the season. He surrendered a two-run homer to Anthony Rizzo in the first inning of Tuesday's game and allowed three hits and four strikeouts before exiting.
Liriano joins right-hander Gerrit Cole (6-3, 3.64 ERA), who was placed there Sunday with right shoulder fatigue.
Tom Singer is a reporter for MLB.com and writes an MLBlog Change for a Nickel. He can also be found on Twitter @Tom_Singer. Stephen Pianovich is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.