Wrapping up a red-hot spring, Rodriguez connected off Bucs Opening Day starter Kevin Correia for a towering first-inning blast that cleared the center field batter's eye for a two-run shot.
Rodriguez's homer, his fifth in eight games, came with Mark Teixeira aboard and supported New York starter Manny Banuelos, as the touted left-hander tunes up to begin his season at Double-A Trenton.
Banuelos limited the Pirates to Jason Jaramillo's second-inning RBI single over three innings, allowing two hits while walking three and striking out three.
2010 Spring Training - null
Sights & Sounds
Spring Training Info
Making his final preparations for his season-opening start against the Cubs at Wrigley Field, the right-hander Correia delivered a quality start, throwing six innings of three-run ball, striking out five while walking two.
"You want your last Spring Training outing to be good," Correia said. "You don't want to go into the season thinking about how you didn't pitch well the time before. I felt pretty good about this one."
The Yankees added a run in the fourth, as newcomer Chris Dickerson, acquired in a trade Friday from the Brewers, stroked an RBI single that knocked in Nick Swisher.
Mariano Rivera hurled a scoreless fourth inning for New York around two hits, striking out one. Rafael Soriano allowed a run -- coming on a Neil Walker sacrifice fly -- in two-thirds of an inning.
Up next for the Pirates: Pittsburgh will play its final spring game at McKechnie Field on Sunday when the Rays come north for a 1:05 p.m. ET contest. This will mark the last of seven meetings between these two clubs this spring. Paul Maholm, who was recently slotted into the No. 2 spot in the rotation, will make his last spring start before taking the mound at Wrigley Field next Saturday. Maholm will be opposed by Tampa Bay's David Price, and he is scheduled to be followed by relievers Joel Hanrahan and Chris Leroux.
Up next for the Yankees: The Bombers hit the highway for their last road game of the spring, traveling to meet the Twins in a 1:05 p.m. ET start in Fort Myers, Fla, on Sunday. Reliever Romulo Sanchez will start for New York, while Alex Rodriguez, Robinson Cano and Mark Teixeira will be among the big bats traveling for the exhibition.
Bryan Hoch is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.