McCutchen sent an 0-2 sinker from Huston Street to the top of the wall in right-center field, where the ball ricocheted back into play and was signaled a home run. Rockies manager Jim Tracy came out from the dugout to dispute the call and after review the play was overturned.
McCutchen would eventually score on Pedro Alvarez's game-winning three-run homer later in the inning.
This happened one night after the Rockies' Dexter Fowler had a home run overturned into a triple by Reilly after Fowler sent a Joel Hanrahan fastball off the top of the wall in left field in the ninth inning.
Saturday's review marked the fifth in PNC Park history, four of which have now been overturned.
McCutchen's double was similar to Colorado's Carlos Gonzalez's triple that led off the fourth inning Saturday, but there were no arguments after that one bounced off the top of the wall in right-center field and onto the field without a signal.
Matt Fortuna is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.